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Lipid Nanoparticles Carry Gene-Editing Cancer Drugs Past Tumor Defenses
As they grow, solid tumors surround themselves with a thick, hard-to-penetrate wall of molecular defenses. Getting drugs past that barricade is notoriously difficult. Now, scientists at UT Southwestern have developed nanoparticles that can break down the physical barriers around tumors to reach cancer cells. Once inside, the nanoparticles release their payload: a gene editing system that alters DNA inside the tumor, blocking its growth and activating the immune system.
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UTSW Researchers Develop Blood Test to Predict Liver Cancer Risk
Protein levels in blood samples of patients with nonalcoholic fatty liver disease reveal those at highest risk who should be screened regularly for liver cancer. Now, UT Southwestern researchers have developed a simple blood test to predict which NAFLD patients are most likely to develop liver cancer.
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An Innovator at the Helm: Chair of Radiation Oncology Plans Big Changes
"Tumors constantly evolve, and that evolution creates opportunities for cancer to elude the ongoing therapy. No single strategy will work. We must have a treatment to uniquely fit the particular patient’s situation." -Robert Timmerman, M.D., Chair of Radiation Oncology
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Outsmarting Cancer
Adaptive radiation therapy represents a paradigm shift in cancer care, and UT Southwestern is leading the charge in delivering these more precise and personalized treatments.
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The ART and Science of Targeting Gynecologic Tumors
Adaptive radiation therapy (ART) – a new patient tumor personalized technology – is now available to treat and cure women with cervical cancer and other gynecologic tumors.
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Simmons Cancer Center’s Dr. John Sweetenham to Chair National Comprehensive Cancer Network Board of Directors
John Sweetenham, M.D., Associate Director for Clinical Affairs at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center, has been elected Chair of the Board of Directors of the National Comprehensive Cancer Network (NCCN).
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Grant Supports UTSW Push to Make Genomic Data More Accessible
Researchers at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center are developing an innovative interface to make the wealth of genomics data from next-generation sequencing visible and actionable in real time for clinicians and researchers.
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DARTBOARD: Novel head & neck cancer trial targets personalized, daily radiation therapy
The DARTBOARD clinical trial will study daily adaptive radiotherapy on head and neck cancers using tumor targeting driven by an AI-driven algorithm developed by UT Southwestern.
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Working to Reduce Cancer Disparities Across Our Community
The Office of Community Outreach, Engagement, and Equity is committed to maximizing the impact of Simmons research through community engagement in the DFW Metroplex and beyond.
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Pioneering Initiatives to Modernize Cancer Care
New developments aim to improve clinical outcomes for cancer patients.
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UT Southwestern Develops Nanotherapeutic to Ward Off Liver Cancer
Physician researchers from UT Southwestern Medical Center have developed an innovative nanotherapeutic drug that prevents cancer from spreading to the liver in mice.
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Clinical Trial Shows Stereotactic Radiation Extends Systemic Therapy and Slows Kidney Cancer Progression
A new study by the Kidney Cancer Program (KCP) at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center shows that highly focused radiation to isolated metastases that progress despite drug therapy can prolong drug efficacy in kidney cancer patients, saving the few other drugs for treating kidney cancer for future use.