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UTSW Clinical Trial Sets Stage for New Paradigm in Kidney Cancer Treatment
Kidney cancer encompasses a wide spectrum and can present with extensive metastases or just a handful. However, today all patients are treated the same. They all receive medication.
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Cell Competition May Explain Cancer Relapses, Research Suggests
A normal process called cell competition, in which healthy tissues eliminate unhealthy cells, could be responsible for cancer relapses in patients months or years after they were declared cancer-free, a new study by UT Southwestern researchers suggests.
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Drug Shows Promise in Overcoming Endocrine Therapy Resistance in Breast Cancer
For patients with estrogen receptor (ER)-positive breast cancer, development of the so-called Y537S mutation signals that their disease has taken an aggressive course and may become resistant to endocrine therapy. Now a preclinical study, led by researchers at UT Southwestern Medical Center, suggests that a class of new drugs already in clinical trials might work especially well in breast cancer patients who have acquired this mutation.
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Breast Cancer Drug Benefits Broader Group of Patients, Trial Shows
A drug approved to treat breast cancer patients with mutations in the BRCA1 or BRCA2 genes may also benefit people who have other genetic mutations.
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Tackling resistance to HIF2 drugs with an RNA-based therapy
Kidney cancer has traditionally been one of the most challenging cancers to treat. Discovered at UT Southwestern Medical Center (UTSW), the HIF2a protein is the most important driver of kidney cancer, which has traditionally been regarded as undruggable.
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UTSW is leading the way toward better screening for liver cancer
Multi-institutional Clinical Validation Center seeks to improve risk assessment and early detection of cancer in patients with cirrhosis
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New recommendations aim to ease patient access to lung cancer clinical trials
A new approach to determining admission could boost enrollment numbers and diversity.
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Robotic Surgery Symposium Brings the Future to Simmons
The latest developments in robotic cancer surgery
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Lipid Nanoparticles Carry Gene-Editing Cancer Drugs Past Tumor Defenses
As they grow, solid tumors surround themselves with a thick, hard-to-penetrate wall of molecular defenses. Getting drugs past that barricade is notoriously difficult. Now, scientists at UT Southwestern have developed nanoparticles that can break down the physical barriers around tumors to reach cancer cells. Once inside, the nanoparticles release their payload: a gene editing system that alters DNA inside the tumor, blocking its growth and activating the immune system.
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UTSW Researchers Develop Blood Test to Predict Liver Cancer Risk
Protein levels in blood samples of patients with nonalcoholic fatty liver disease reveal those at highest risk who should be screened regularly for liver cancer. Now, UT Southwestern researchers have developed a simple blood test to predict which NAFLD patients are most likely to develop liver cancer.
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An Innovator at the Helm: Chair of Radiation Oncology Plans Big Changes
"Tumors constantly evolve, and that evolution creates opportunities for cancer to elude the ongoing therapy. No single strategy will work. We must have a treatment to uniquely fit the particular patient’s situation." -Robert Timmerman, M.D., Chair of Radiation Oncology
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The ART and Science of Targeting Gynecologic Tumors
Adaptive radiation therapy (ART) – a new patient tumor personalized technology – is now available to treat and cure women with cervical cancer and other gynecologic tumors.