Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

Rodney Infante, M.D., Ph.D., a UT Southwestern specialist in general gastroenterology and cancer cachexia at UT Southwestern Medical Center is a co-author on a newly published research article discussing cancer cachexia, a wasting syndrome characterized by muscle and adipose loss that subsequently leads to weight decrement. It is observed in 50% of all patients with solid tumors, responsible for 30% of all cancer-related deaths, and associated with reduced cancer survival and quality of life.

Original Article: https://insight.jci.org/articles/view/165419