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The ILLUMINATE Study

The ILLUMINATE Study

Our clinical research team is conducting a Phase-2 clinical trial with a drug, pegsitacianine based on the fluorescent nanoparticles developed in our lab.

Fluorescent nanoprobe lights the way to reducing spread of cancer cells

Fluorescent nanoprobe lights the way to reducing spread of cancer cells

Healthy cells “eat” glucose, or sugar, to gain energy, divide, and heal themselves. Cancer cells, by comparison, consume glucose at a much higher volume to change their makeup, grow, and spread. The resulting byproduct is a tumor that secretes high levels of lactic acid, crippling the immune system’s defenses against the cancer.

Using nanotechnology to attack cancer’s Achilles’ heel: acidity

Using nanotechnology to attack cancer’s Achilles’ heel: acidity

Although cancers come in many forms, they all have a lower pH than normal tissue. Pharmacologist Jinming Gao, Ph.D., and head and neck surgeon Baran Sumer, M.D., have been working together for years on a pH-sensitive technology that can help surgeons more precisely excise tumors and help anti-tumor drugs get exactly where they need to be.

Illuminating cancer: New pH threshold sensor improves cancer surgery

Illuminating cancer: New pH threshold sensor improves cancer surgery

The high acidity of cancer cells yielded the clue that led to the development of a tool that significantly improves surgeons’ abilities to remove cancerous tissues. The invention by UT Southwestern researchers is a transistor-like threshold sensor that hones in on high pH, literally lighting up cancerous cells.

UT Southwestern researchers seek to light up cancer cells so surgeons can better see where to cut

UT Southwestern researchers seek to light up cancer cells so surgeons can better see where to cut

Baran Sumer, M.D. Professor and Chief of the Division of Head and Neck Oncology in UT Southwestern’s Department of Otolaryngology and a team of researchers from the Simmons Comprehensive Cancer Center developed a technology called a pH Nanosensor, an injection that seeks out cancerous areas in the body and causes them to light up.

A transistor-like pH nanoprobe for tumour detection and image-guided surgery

A transistor-like pH nanoprobe for tumour detection and image-guided surgery

UT Southwestern’s Baran Sumer, M.D., Professor and Chief of the Division of Head and Neck Oncology in the Department of Otolaryngology is among other researchers to report the design and performance of a fluorescent nanoprobe with transistor-like responses (transition pH?=?6.9) for the detection of deregulated pH, which drives many of the invasive properties of cancer.

Nanoparticles developed at UTSW effectively fight tumors

Nanoparticles developed at UTSW effectively fight tumors

Activating a specific pathway in a subset of immune cells eradicates immunologically ‘cold’ tumors, UTSW study shows

UT Southwestern Voice Center Study Profiles Hundreds of Injured Singers

UT Southwestern Voice Center Study Profiles Hundreds of Injured Singers

Analysis identifies most common conditions and treatments

Middle Ear Fluid Common in Kids on Ventilators, UTSW Study Finds

Middle Ear Fluid Common in Kids on Ventilators, UTSW Study Finds

The research, which followed 94 babies and toddlers at Children’s Medical Center Dallas, could lead to interventions to prevent hearing and speech problems.

UTSW Study Recommends Screening for Suspected Obstructive Sleep Apnea in Underweight Children

UTSW Study Recommends Screening for Suspected Obstructive Sleep Apnea in Underweight Children

Researchers at UT Southwestern Medical Center studied obstructive sleep apnea in a large group of children and concluded that underweight children with this condition are more likely to have decreased height, tonsillar hypertrophy, and allergic rhinitis.