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The Future of Medicine Sparks Here
This is UT Southwestern Medical Center, and this is where a spark happens. Join UT Southwestern Medical Center and find your spark.
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The ILLUMINATE Study
Our clinical research team is conducting a Phase-2 clinical trial with a drug, pegsitacianine based on the fluorescent nanoparticles developed in our lab.
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Fluorescent nanoprobe lights the way to reducing spread of cancer cells
Healthy cells “eat” glucose, or sugar, to gain energy, divide, and heal themselves. Cancer cells, by comparison, consume glucose at a much higher volume to change their makeup, grow, and spread. The resulting byproduct is a tumor that secretes high levels of lactic acid, crippling the immune system’s defenses against the cancer.
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Using nanotechnology to attack cancer’s Achilles’ heel: acidity
Although cancers come in many forms, they all have a lower pH than normal tissue. Pharmacologist Jinming Gao, Ph.D., and head and neck surgeon Baran Sumer, M.D., have been working together for years on a pH-sensitive technology that can help surgeons more precisely excise tumors and help anti-tumor drugs get exactly where they need to be.
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Illuminating cancer: New pH threshold sensor improves cancer surgery
The high acidity of cancer cells yielded the clue that led to the development of a tool that significantly improves surgeons’ abilities to remove cancerous tissues. The invention by UT Southwestern researchers is a transistor-like threshold sensor that hones in on high pH, literally lighting up cancerous cells.
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UT Southwestern researchers seek to light up cancer cells so surgeons can better see where to cut
Baran Sumer, M.D. Professor and Chief of the Division of Head and Neck Oncology in UT Southwestern’s Department of Otolaryngology and a team of researchers from the Simmons Comprehensive Cancer Center developed a technology called a pH Nanosensor, an injection that seeks out cancerous areas in the body and causes them to light up.
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A transistor-like pH nanoprobe for tumour detection and image-guided surgery
UT Southwestern’s Baran Sumer, M.D., Professor and Chief of the Division of Head and Neck Oncology in the Department of Otolaryngology is among other researchers to report the design and performance of a fluorescent nanoprobe with transistor-like responses (transition pH?=?6.9) for the detection of deregulated pH, which drives many of the invasive properties of cancer.
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Cancer Researchers are “Lighting Up” Cancer
Learn how cancer researchers are “lighting up” cancer by watching our Facebook Live chat with otolaryngologist Baran Sumer, M.D. Dr. Sumer is part of a team that developed a transistor-like nanosensor that can illuminate cancerous cells to assist surgeons.
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Factors Associated with Lymph Node Count in Head and Neck Cancer
Surgeons from the University of Texas Southwestern Medical Center carried-out a restrospective study on 247 patients with head and neck cancer to test whether age and undernutrition, factors known to negatively affect immune function, decreased lymph-node count in patients undergoing neck dissection.
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Nanoparticles developed at UTSW effectively fight tumors
Activating a specific pathway in a subset of immune cells eradicates immunologically ‘cold’ tumors, UTSW study shows
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UT Southwestern Voice Center Study Profiles Hundreds of Injured Singers
Analysis identifies most common conditions and treatments
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Middle Ear Fluid Common in Kids on Ventilators, UTSW Study Finds
The research, which followed 94 babies and toddlers at Children’s Medical Center Dallas, could lead to interventions to prevent hearing and speech problems.